It depends on you, and the situation of the product, so if it is a product existing for some time, then you must know which variation performs the best out of all, you can simply target that to minimize the spending and maximize the profit/sales, however, if your product is new and you don’t have any idea, then you can simply target all the child ASINs, and let them run, until you see clear winners, pause the rest of the ASINs.